Our publications

Selected publications are listed below. Our research has been funded by the Canadian Institutes of Health Research, the Canada Foundation for Innovation, the Natural Sciences and Engineering Research Council of Canada, and the Fonds de la Recherche en Santé du Québec.

  • Timofeeva E, Caron A, Richard D (2017)
    Energy homeostasis: paraventricular nucleus system. In book: Reference Module in Neuroscience and Biobehavioral Psychology, Chapter: Hypothalamic Arcuate and Paraventricular Nuclei, Publisher: Elsevier, Editors: John Stein. dio: 10.1016/B978-0-12-809324-5.02753-X
Click on image to enlarge or download Timofeeva E, Caron A, Richard D (2017) Energy homeostasis: paraventricular nucleus system. In book: Reference Module in Neuroscience and Biobehavioral Psychology, Chapter: Hypothalamic Arcuate and Paraventricular Nuclei, Publisher: Elsevier, Editors: John Stein. dio: 10.1016/B978-0-12-809324-5.02753-X

The neuroendocrine paraventricular nucleus and the regulation of energy balance. The paraventricular nucleus (a) corticotropin-releasing factor (CRF) and (b) thyrotropin releasing hormone (TRH) cells project to the anterior pituitary, where they control the release of glucocorticoids and thyroid hormones. Glucocorticoids enhance visceral fat deposition by increasing food intake and reducing energy expenditure, whereas thyroid hormones reduce fat deposition by decreasing the food intake/thermogenesis ratio. The parvicellular neurosecretory division that contains the CRF and TRH cells is highly innervated by neurons originating from regions strategically positioned to relay signals informing about nutritional status and energy homeostasis.
ACTH, adrenocorticotropic hormone; AGRP, agouti-related protein; AR, adrenergic receptor; ARC, arcuate nucleus; BST, bed nucleus of the stria terminalis; E, epinephrine; GABA, g-aminobutyric acid; 5HT, 5-hydroxytryptamine; LH, lateral hypothalamus; MC4R, melanocortin receptor 4; MSH, melanocyte-stimulating hormone; NE, norepinephrine; NPY, neuropeptide Y; ORX, orexins; OXR, orexin receptors; T3, triiodothyronine; T4, thyroxine; TRH, thyrotropinreleasing hormone; TSH, thyroid-stimulating hormone; Y1, NPY receptor 1.

  • Kania A, Czerw A, Grabowiecka A, de Ávila C, Blasiak T, Rajfur Z, Lewandowski MH, Hess G, Timofeeva E, Gundlach AL, Blasiak A (2017)
    Modulation of oxytocin and vasopressin neuron activity in rat PVN by relaxin-3/RXFP3 signalling. J Physiol (London), in press. doi: 10.1113/JP273787
Click on image to enlarge or download Kania A, Czerw A, Grabowiecka A, de Ávila C, Blasiak T, Rajfur Z, Lewandowski MH, Hess G, Timofeeva E, Gundlach AL, Blasiak A (2017) Modulation of oxytocin and vasopressin neuron activity in rat PVN by relaxin-3/RXFP3 signalling. J Physiol (London), in press. doi: 10.1113/JP273787

A, Relaxin-3 (RLN3) inhibits paraventricular hypothalamic nucleus (PVN) type I neurons via a cognate RLN3 receptor RXFP3. In the PVN, arginine vasopressin neurons (B, C, brown staining) and oxytocin neurons (D, E, brown staining) co-express RXFP3 mRNA (black silver grains in B-E). .

  • Haidar M, Gučvremont G, Zhang C, Bathgate RAD, Timofeeva E, Smith CM, Gundlach AL (2017)
    Relaxin-3 inputs target hippocampal interneurons and deletion of hilar relaxin-3 receptors in "floxed-RXFP3" mice impairs spatial memory. Hippocampus, in press. doi: 10.1002/hipo.22709
Click on image to enlarge or download Haidar M, Gučvremont G, Zhang C, Bathgate RAD, Timofeeva E, Smith CM, Gundlach AL (2017) Relaxin-3 inputs target hippocampal interneurons and deletion of hilar relaxin-3 receptors in

Comparative distribution of eGFP, Cre-recombinase and somatostatin (SST) in hilar neurons of dorsal hippocampus in mice injected with the AAV(1/2)-Cre-IRES-eGFP viral vector. Bilateral injections of AAV(1/2)-Cre-IRES-eGFP into the DG of floxed-RXFP3 mice resulted in expression of eGFP (A) and Cre-immunoreactivity (B) in neurons of the DG hilus. Cre-immunoreactivity and endogenous eGFP immunofluorescence were consistently observed in SST-immunoreactive neurons in the region (C, D).

Click on image to enlarge or download Haidar M, Gučvremont G, Zhang C, Bathgate RAD, Timofeeva E, Smith CM, Gundlach AL (2017) Relaxin-3 inputs target hippocampal interneurons and deletion of hilar relaxin-3 receptors in

Effect of an AAV(1/2)-Cre-IRES-eGFP or an AAV(1/2)-eGFP viral vector injection into the dorsal DG hilus of floxed-RXFP3 mice on levels of RXFP3 mRNA in the target and CA3 regions, and a schematic illustration of the virus distribution observed.

  • Calvez J, de Avila C, Timofeeva E (2017)
    Sex-specific effects of relaxin-3 on food intake and body weight gain. Br J Pharmacol, 174: 1049-1060. doi: 10.1111/bph.13530. Link
Click on image to enlarge or download Calvez J, de Avila C, Timofeeva E (2016) Sex-specific effects of relaxin-3 on food intake and body weight gain. Br J Pharmacol, doi: 10.1111/bph.13530. [Epub ahead of print]

Relative changes induced by intracerebroventricular (icv) administration of relaxin-3 (RLN3) in the brain and on food intake and body weight gain in female rats compared to male rats. The upward and downward arrows show relatively higher or lower, respectively, effects produced in female rats compared to male rats. BNST, bed nucleus of the stria terminalis; CRF, corticotropin releasing factor; LHA, lateral hypothalamic area; PVN, paraventricular hypothalamic nucleus.

  • Calvez J, de Avila C, Gučvremont G, Timofeeva E (2016)
    Sex-specific effects of chronic administration of relaxin-3 on food intake, body weight and hypothalamo-pituitary-gonadal axis in rats. J Neuroendocrinol, 28(12). doi: 10.1111/jne.12439
Click on image to enlarge or download Calvez J, de Avila C, Gučvremont G, Timofeeva E (2016) Sex-specific effects of chronic administration of relaxin-3 on food intake, body weight and hypothalamo-pituitary-gonadal axis in rats. J Neuroendocrinol, 28(12). doi: 10.1111/jne.12439

Relaxin-3 (RLN3) stimulates the hypothalamic pituitary gonadal axis (HPG) in male rats by increasing the plasma levels of luteinizing hormone (LH, C) and follicle-stimulating hormone (FSH, l D). Conversely, RLN3 inhibits the HPG in female rats by downregulating expression of gonadotropin-releasing hormone (GnRH) in the medial preoptic area (MPOA, A and B) and the levels of plasma estradiol (F). The effects of RLN3 apparently are not directly mediated by RXFP3, a cognate receptor of RLN3, because only about 3% of GnRH-immunoreactive (-ir) neurons co-express RXFP3 mRNA (B1).

  • Calvez J, de Avila C, Guèvremont G, Timofeeva E (2016)
    Stress differentially regulates brain expression of corticotropin-releasing factor in binge-like eating prone and resistant female rats. Appetite, 107:585-595. doi: 10.1016/j.appet.2016.09.010. Link
Click on image to enlarge or download Calvez J, de Avila C, Guèvremont G, Timofeeva E (2016) Stress differentially regulates brain expression of  corticotropin-releasing factor in binge-like eating prone and resistant female  rats. Appetite, 107:585-595. doi:  10.1016/j.appet.2016.09.010.

Female Sprague-Dawley rats were assigned to the binge-like eating prone (BEP) or the binge-like eating resistant (BER) phenotypes according to the rats’ persistently high or low sucrose intake following three stress sessions. Stress triggered a significant increase in plasma corticosterone levels and strongly increased corticotropin-releasing factor (CRF) mRNA expression in the paraventricular hypothalamic nucleus in the BER but not in the BEP rats. However, the BEP but not the BER rats demonstrated a significant increase in CRF mRNA expression in the bed nucleus of the stria terminalis (BNST) after stress. Hyporeactivity of the hypothalamic-pituitary-adrenal axis and the higher CRF expression in the BNST in BEP rats may contribute to stress-induced binge-like sucrose eating in the BEP phenotype.

  • Mitra A, Guèvremont G, Timofeeva E (2016)
    Stress and sucrose intake modulate neuronal activity in the anterior hypothalamic area in rats. PloS One, 11(5): e0156563. doi: 10.1371/journal.pone.0156563. Link
Click on image to enlarge or download Mitra A, Gučvremont G, Timofeeva E (2016) Stress and sucrose intake modulate neuronal activity in the anterior hypothalamic area in rats. PloS One, 11(5): e0156563. doi: 10.1371/journal.pone.0156563

Sucrose-inhibited but not sucrose-excited or sucrose-nonresponsive neurons increased firing rate in response to stress. In addition stress disrupted correlation between sucrose-inhibited and sucrose-nonresponsive neurons.

  • Calvez J, Timofeeva E (2016)
    Behavioral and hormonal responses to stress in binge-like eating prone female rats.
    Physiol Behav, 157: 28-38. doi: 10.1016/j.physbeh.2016.01.029. Link
Click on image to enlarge or download Behavioral and hormonal responses to stress in binge-like eating prone female rats. Physiol Behav, 157: 28-38. doi: 10.1016/j.physbeh.2016.01.029
  • Calvez J, de Avila C, Matte LO, Gučvremont G, Gundlach AL, Timofeeva E (2016)
    Role of relaxin-3/RXFP3 system in stress-induced binge-like eating in female rats. Neuropharmacology, 102: 207-215. doi: 10.1016/j.neuropharm.2015.11.014 Link
Click on image to enlarge or download Calvez J, de Avila C, Matte LO, Gučvremont G, Gundlach AL, Timofeeva E (2016) Role of relaxin-3/RXFP3 system in stress-induced binge-like eating in female rats. Neuropharmacology, 102: 207-215. doi: 10.1016/j.neuropharm.2015.11.014

- We developed a model of binge eating prone (BEP) and binge eating resistant (BER) rats
- BEP rats displayed elevated consumption of sucrose under non-stressful conditions (30% >BER)
- Stress induced additional marked increase in sucrose intake (60% >BER) in BEP rats
- Expression of relaxin-3 and its receptor RXFP3 was increased by stress in BEP rats
- RXFP3 antagonist blocked stress-induced increase in sucrose intake in BEP rats

  • Clavez J, Lenglos C, de Avila C, Gučvremont G, Timofeeva E (2015)
    Differential effects of central administration of relaxin-3 on food intake and hypothalamic neuropeptides in male and female rats. Genes Brain Behav, 14(7): 550-563. doi: 10.1111/gbb.12236. Link
Click on image to enlarge or download Clavez J, Lenglos C, de Avila C, Gučvremont G, Timofeeva E (2015) Differential effects of central administration of relaxin-3 on food intake and hypothalamic neuropeptides in male and female rats. Genes Brain Behav, 14(7): 550-563. doi: 10.1111/gbb.12236.

Relaxin-3 produces stronger orexigenic effects and stronger activation of orexin mRNA expression in the lateral hypothalamus in female rats.

  • Mitra A, Lenglos C, Timofeeva E (2015)
    Inhibition in the lateral septum increases sucrose intake and decreases anorectic effects of stress. Eur J Neurosci, 41 (4): 420-433. doi: 10.1111/ejn.12798. Link
Click on image to enlarge or download Mitra A, Lenglos C, Timofeeva E (2014) Inhibition in the lateral septum increases sucrose intake and decreases anorectic effects of stress. Eur J Neurosci. 2014 Nov 24. doi: 10.1111/ejn.12798. [Epub ahead of print]

The development of sucrose overeating by repeated weekly cycles of food restriction was accompanied by (1) a decrease in the anorectic effects of stress and stress-induced c-fos expression in the lateral septum (LS), (2) an increase in expression of GAD67 in the LS, and (3) an increase in the percentage of LS neurons inhibited at the start of sucrose licking. Direct inhibition of the LS by baclofen decreased the anorectic effects of stress and increased sucrose intake.

  • Lenglos C, Calvez J, Timofeeva E (2014)
    Sex-specific effects of relaxin-3 on food intake and brain expression of corticotropin-releasing factor in rats. Endocrinology, 156 (2): 523-533. Link
Click on image to enlarge or download Lenglos C, Calvez J, Timofeeva E (2014) Sex-specific effects of relaxin-3 on food intake and brain expression of corticotropin-releasing factor in rats. Endocrinology, 156 (2): 523-533.

Central administration of relaxin-3 strongly activates the hypothalamic-pituitary-adrenal axis in male but not female rats.

  • Lenglos C, Calvez J, Timofeeva E (2014)
    The role of relaxin-3 and its receptor RXFP3 in defense of elevated body weight in diet-induced obesity. Receptor Clin Invest, 1: e222 (1-15). Link
Click on image to enlarge or download Lenglos C, Calvez J, Timofeeva E (2014) The role of relaxin-3 and its receptor RXFP3 in defense of elevated body weight in diet-induced obesity. Receptor Clin Invest, 1: e222 (1-15).

The review discusses mechanisms involved in maintenance and defence against caloric restriction of elevated body weight in diet-induced obesity (DIO). One of the mechanisms is the increased expression of neuropeptide relaxin-3 which orexigenic effect is amplified by an increase in the expression of relaxin-3 receptor in specific brain regions during refeeding after food deprivation in DIO rats.

  • Mitra A, Lenglos C, Timofeeva E (2014)
    Activation of GABAA and GABAB receptors in the lateral septum increases sucrose intake by differential stimulation of sucrose licking activity. Behav Brain Res, 273: 82-88. Link
Click on image to enlarge or download Mitra A, Lenglos C, Timofeeva E (2014) Activation of GABAA and GABAB receptors in the lateral septum increases sucrose intake by differential stimulation of sucrose licking activity. Behav Brain Res, 273: 82-88.

Highlights:
- Injection of muscimol and baclofen into the lateral septum increased sucrose intake
- Muscimol but not baclofen decreased the latency to initiate sucrose licking
- Baclofen but not muscimol increased the total licking time

  • Calvez J, Timofeeva E (2014)
    Neuronal substrate of eating disorders. Brain Disord Ther, 3: 121 (1-15). Link
Click on image to enlarge or download Calvez J, Timofeeva E (2014) Neuronal substrate of eating disorders. Brain Disord Ther, 3: 121 (1-15).

Eating disorders are devastating and life-threatening psychiatric diseases. Although clinical and experimental investigations have significantly progressed in discovering the neuronal causes of eating disorders, the exact neuronal and molecular mechanisms of the development and maintenance of these pathologies are not fully understood. The complexity of the neuronal substrate of eating disorders hampers progress in revealing the precise mechanisms. The present review describes the current knowledge on the implication of the neuronal systems that regulate food intake, stress, emotions, and reward in eating disorders. The current data based on clinical and experimental research strongly suggest that these systems are interconnected and a misbalance in one system leads to altered activity in other food-related regulatory networks.

  • Giordano C, Marchiň M, Timofeeva E, Biagini G (2014)
    Neuroactive peptides as putative mediators of antiepileptic ketogenic diets. Front Neurol,
    5: 1-14. Link
  • Lenglos C, Mitra A, Gučvremont G, Timofeeva E (2014)
    Regulation of expression of relaxin-3 and its receptor RXFP3 in the brain of diet-induced obese rats. Neuropeptides, 48: 119-132. Link

The diet-induced obesity (DIO) rats show a constitutive increase in relaxin-3 expression in the medial nucleus incertus (NI). The stronger expression of relaxin-3 in the NI in DIO rats was accompanied by low expression of the cognate relaxin-3 receptor RXFP3 in the paraventricular hypothalamic nucleus (PVN), supraoptic nucleus, central amygdala (CeA), NI, and nucleus of the solitary tract (NTS). Refeeding increased expression of RXFP3 in the paraventricular thalamic nucleus, parvocellular PVN, CeA, NI, and NTS in the DIO rats. These results provide evidence that DIO rats show a constitutive increase in relaxin-3 expression in the medial NI and that refeeding after food deprivation may enhance the orexigenic effects of relaxin-3 in DIO rats by rapid upregulation of the expression of RXFP3 in the specific brain regions involved in food intake regulation.

  • Lenglos C, Mitra A, Gučvremont G, Timofeeva E (2013)
    Sex difference in regulation of body weight, HPA axis activity and relaxin-3 expression in rats. Genes Brain and Behav, 12 (4): 370-387. Link
Click on image to enlarge or download Lenglos C, Mitra A, Gučvremont G, Timofeeva E (2013) Sex difference in regulation of body weight, HPA axis activity and relaxin-3 expression in rats. Genes Brain and Behav, 12 (4): 370-387.

Chronic stress and repeated food restriction decreased body weight gain in male rats. Conversely, chronic stress and repeated food restriction increased body weight gain in female rats.
Female chronically stressed and repeatedly food-restricted rats significantly increased brainstem (NI) expression of orexigenic neuropeptide relaxin-3 and significantly decreased hypothalamic (PVN) expression of anorexigenic neuropeptide corticotropin releasing factor (CRF).

  • Timofeeva E and Mitra A (2013)
    Chapter 5: The effects of sucrose on neuronal activity. In: Sucrose, Properties, Biosynthesis and Health Implication. Ed: Magazu S. Hauppauge NY: Nova Science Publishers, pp. 75-113. Link
Click on image to enlarge or download Timofeeva E and Mitra A (2013) Chapter 5: The effects of sucrose on neuronal activity. In: Sucrose, Properties, Biosynthesis and Health Implication. Ed: Magazu S. Hauppauge NY: Nova Science Publishers, pp. 75-113.

The neuronal network activated by sucrose intake
Contents of chapter 5:
1. Introduction. Statistics shows that we have dramatically increased our sugar production and intake over the last several centuries.
2. The neuronal network activated by sucrose.
3. Why do we consume more sugar than we should, according to our metabolic needs?
4. Why sugar is comforting during stress?
5. Could sucrose be addictive?
6. Conclusion.

  • Poulin AM, Lenglos C, Mitra A, and Timofeeva E (2012)
    Hypothalamic expression of urocortin 3 and the type 2 corticotropin-releasing factor receptor is regulated according to feeding state in lean but not obese Zucker rats. Neuropharmacology, 63(1): 147-153. Link
Click on image to enlarge or download Poulin AM, Lenglos C, Mitra A, and Timofeeva E (2012) Hypothalamic expression of urocortin 3 and the type 2 corticotropin-releasing factor receptor is regulated according to feeding state in lean but not obese Zucker rats. Neuropharmacology, 63(1): 147-153.
Click on image to enlarge or download Poulin AM, Lenglos C, Mitra A, and Timofeeva E (2012) Hypothalamic expression of urocortin 3 and the type 2 corticotropin-releasing factor receptor is regulated according to feeding state in lean but not obese Zucker rats. Neuropharmacology, 63(1): 147-153.

The low levels of ventromedial hypothalamic nucleus (VMH) corticotropin releasing factor type 2 receptor (CRF2-R) may limit anorexigenic urocortin-3 (Ucn3) effects in the obese phenotype. The low VMH CRF2-R levels at the beginning of refeeding in lean rats may allow them to ingest a considerable amount of food regardless of the rapidly increased expression of Ucn3 by refeeding in this phenotype.

  • Baraboi ED, Timofeeva E, St-Pierre D, and Richard D (2011)
    Brain activation following peripheral administration of the GLP-1 receptor agonist exendin-4. Am J Physiol, 301(4): R1011-R1024. Link
  • Mitra A, Lenglos C, Martin J, Mbende N, Gagné A, and Timofeeva E (2011)
    Sucrose modifies c-fos mRNA expression in the brain of rats maintained on feeding schedules. Neuroscience, 192: 459-474. Link
Click on image to enlarge or download Mitra A, Lenglos C, Martin J, Mbende N, Gagné A, and Timofeeva E (2011) Sucrose modifies c-fos mRNA expression in the brain of rats maintained on feeding schedules. Neuroscience, 192: 459-474.
Click on image to enlarge or download Mitra A, Lenglos C, Martin J, Mbende N, Gagné A, and Timofeeva E (2011) Sucrose modifies c-fos mRNA expression in the brain of rats maintained on feeding schedules. Neuroscience, 192: 459-474.
  • Roy C, Roy MC, Gauvreau D, Poulin AM, Tom FQ, Timofeeva E, Richard D, and Cianflone K (2011)
    Acute injection of ASP in the third ventricle inhibits food intake and locomotor activity in rats. Am J Physiol, 301 (1): E232-241. Link
  • Timofeeva E (2010)
    Yin and yang in regulation of alcohol and sucrose intake by CRF1 and CRF2 receptors. Can J Addiction Med, 1 (3): 4-11. PDF Format, 2,55 Mb
  • Martin J and Timofeeva E (2010)
    Intermittent access to sucrose increases sucrose licking activity and attenuates stress-induced activation of the lateral septum. Am J Physiol, 298: R1383-R1398. PDF Format, 4,98 Mb
Click on image to enlarge or download Martin J and Timofeeva E (2010) Intermittent access to sucrose increases sucrose licking activity and attenuates stress-induced activation of the lateral septum. Am J Physiol, 298: R1383-R1398.

Intermittent access to sucrose decreases anorectic effects of chronic stress and decreases stress-induced neuronal activation (induction of expression of c-fos mRNA, shown on the photomicrographs) in the lateral septum (LS).

Publications 1996 - 2009+

  • Timofeeva E, Baraboi ED, Poulin AM, and Richard D (2009)
    Palatable high-energy diet decreases the expression of cannabinoid type 1 receptor (CB1R) mRNA in specific brain regions in rat. J Neuroendocrinology, 21: 982-992. Link
  • Richard D, Guesdon B, and Timofeeva E (2009)
    The brain endocannabinoid system in the regulation of energy balance. Best Practice & Research Clinical Endocrinology & Metabolism, 23: 17-32. Link
  • Poulin AM and Timofeeva E (2008)
    The dynamics of neuronal activation during food anticipation and feeding in the brain of food-entrained rats. Brain Research, 1227: 128-141. Link
  • Furuta T, Timofeeva E, Nakamura K, Okamoto-Furuta K, Togo M, Kaneko T, and Deschęnes M (2008)
    Inhibitory gating of vibrissal inputs in the brainstem. J Neurosci, 28: 1789-1797. Link
  • Huang Q, Timofeeva E, and Richard D (2006)
    Corticotropin-releasing factor and its receptors in the brain of rats with insulin and corticosterone deficits. J Mol Endocrin, 37: 213-226. PDF Format, 1,16 Mb
  • Huang Q, Timofeeva E, and Richard D (2006)
    Regulation of corticotrophin-releasing factor and its type-1 and typr-2 alpha receptors by leptin in rats subjected to treadmill running-induced stress. J Endocrin, 191: 179-188. PDF Format, 617 Kb
  • Timofeeva E, Baraboi ED, and Richard D (2005)
    Contribution of the vagus nerve and lamina terminalis to brain activation induced by refeeding. Eur J Neurosci 22: 1489-1501. Link
  • Timofeeva E, Dufresne C, Sik A, Zhang ZW, and Deschęnes M (2005)
    Cholinergic modulation of vibrissal receptive fields in trigeminal nuclei. J Neurosci 25: 9135-9143. Link
  • Deschęnes M, Timofeeva E, Lavalleé P, and Dufresne C (2005)
    The vibrissal system as a model of thalamic operations. Prog Brain Res 149: 31-40. Link
  • Duclos M, Timofeeva E, Michel C, and Richard D (2005)
    Corticosterone-dependent metabolic and neuroendocrine abnormalities in obese Zucker rats in relation to feeding. Am J Physiol Endocrinol Metab 288: E254-E266. PDF Format, 1,72 Mb
  • Timofeeva E, Lavallee P, Arsenault D, and Deschęnes M (2004)
    Synthesis of multiwhisker-receptive fields in subcortical stations of the vibrissa system. J Neurophysiol 91: 1510-1515. Link
  • Timofeeva E, Merette C, Emond C, Lavalleé P, and Deschęnes M (2003)
    A map of angular tuning preference in thalamic barreloids. J Neurosci 23: 10717-10723. Link
  • Deschęnes M, Timofeeva E, and Lavalleé P (2003)
    The relay of high-frequency sensory signals in the whisker-to-barreloid pathway. J Neurosci 23: 6778-6787. Link
  • Timofeeva E, Huang Q, and Richard D (2003)
    Effects of treadmill running on brain activation and the corticotropin-releasing hormone system. Neuroendocrinology 77: 388-405. Link
  • Timofeeva E, Picard F, Duclos M, Deshaies Y, and Richard D (2002)
    Neuronal activation and corticotropin-releasing hormone expression in the brain of obese (fa/fa) and lean (fa/?) Zucker rats in response to refeeding. Eur J Neurosci 15: 1013-1029. Link
  • Richard D, Lin Q, and Timofeeva E (2002)
    The corticotropin-releasing factor family of peptides and CRF receptors: their roles in the regulation of energy balance. Eur J Pharmacol 440: 189-197. Link
  • Timofeeva E and Richard D (2001)
    Activation of the central nervous system in obese Zucker rats during food deprivation. J Comp Neurol 441: 71-89. Link
  • Richard D, Huang Q, and Timofeeva E (2000)
    The corticotropin-releasing hormone system in the regulation of energy balance in obesity. Int J Obes Relat Metab Disord 24 Suppl 2: S36-S39. Link
  • Picard F, Richard D, Timofeeva E, and Deshaies Y (2000)
    Abnormal insulin and beta-adrenergic modulation of lipoprotein lipase during refeeding after prolonged fasting in the Zucker rat. Diabetologia 43: 866-874. Link
  • Timofeeva E, Deshaies Y, Picard F, and Richard D (1999)
    Corticotropin-releasing hormone-binding protein in brain and pituitary of food-deprived obese (fa/fa) Zucker rats. Am J Physiol 277: R1749-R1759. PDF Format, 807 Kb
  • Timofeeva E and Richard D (1997)
    Functional activation of CRH neurons and expression of the genes encoding CRH and its receptors in food-deprived lean (Fa/?) and obese (fa/fa) Zucker rats. Neuroendocrinology 66: 327-340. Link
  • Richard D, Rivest R, Naimi N, Timofeeva E, and Rivest S (1996)
    Expression of corticotropin-releasing factor and its receptors in the brain of lean and obese Zucker rats. Endocrinology 137: 4786-4795. Link